THOUGHTS ON THIS? (And the AMAZING history of GLP1)• - By now most everyone has heard of Ozempic and other drugs for weight loss. The origin of those peptides is remarkable. Biologists studying the Gila monster understood that it’s an animal that eats very seldom which means that it either is a) very hungry a lot of its life or b) that its hunger is somehow suppressed. Turns out it’s the latter. - By analyzing the venom of the Gila monster they discovered a peptide called extendin, which is homologous (similar) to what is now known to be glucagon like peptide 1 or GLP1. It suppresses hunger by acting on the brain and the gut. - A similar peptide was discovered in mammals: GLP1, including humans. It also suppresses hunger by acting at the level of the brain and the gut. (There’s more to the story, but that’s the gist). - Fast-forward to 2017 when Ozempic was approved for use in adults with type 2 diabetes. later, it was approved for chronic weight management and is nowadays one of the most popular compounds for that purpose. - The photo in this picture is real, and speaks to the popularity of Ozempic. Soon I’ll host an expert on obesity. There’s also an episode coming up about peptides and hunger on the Huberman Lab podcast. Meanwhile, I would love your thoughts on anything related to this post. I was surprised to see the sign in front of the store. I don’t know that I’ve ever seen anything like it, but it speaks to the popularity and interest in Gila monsters. OK, maybe not, but it certainly speaks to a number of important themes in human and public health. - Please put any questions or comments in the comments section below, and as always, thank you for your interest in science! - @hubermanlab @stanford.med @stanford - #neuroscience #science #ciencia #neurociencia #weight #satiety #glp1